Saxenda vs. Ozempic: A Comprehensive Guide for Weight Loss and Diabetes Management in Australia

In Australia, managing obesity and type 2 diabetes is a critical health priority, given their rising prevalence and associated health risks.

Two significant medications used in addressing these issues are Saxenda (liraglutide) and Ozempic (semaglutide).

Both are part of the GLP-1 receptor agonist class but serve different primary purposes and come with distinct profiles.

his article explores Saxenda and Ozempic, delving into their uses, side effects, differences, and alternatives available in Australia now that Saxenda is in the process of being discontinued in Australia, and will no longer be available from December 2025.

What is Ozempic? 

Ozempic (semaglutide) is a medication primarily used to treat type 2 diabetes.

It functions by mimicking the GLP-1 hormone, which enhances insulin secretion, reduces glucagon release, and slows gastric emptying, leading to better blood sugar control.

In addition to its primary use, Ozempic has also been shown to support weight loss, making it a dual-benefit drug for those managing both diabetes and obesity.

Ozempic Australia is widely recognized for its effectiveness in managing these conditions. 

What is Saxenda? 

Saxenda (liraglutide) is a medication specifically approved for weight management.

It is prescribed for adults with a body mass index (BMI) of 30 or higher (obesity) or those with a BMI of 27 or higher (overweight) who have weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol.

Saxenda helps with weight loss by acting on areas of the brain that regulate appetite, leading to reduced hunger and increased feelings of fullness.

As of December 2025, Saxenda will no longer be available in Australia. Novo Nordisk made the decision to discontinue the medication in favour of Wegovy, which has shown superior efficacy in weight loss.

Are there any side effects of Ozempic or Saxenda? 

Like any medication, Ozempic and Saxenda can cause side effects. Common side effects include: 

• Nausea 
• Vomiting 
• Diarrhea 
• Abdominal pain 
• Constipation 
• Headache 
• Low blood sugar (hypoglycemia) 

Less common but more severe side effects can include: 

• Pancreatitis 
• Gallbladder problems 
• Kidney problems 
• Allergic reactions 
• Low mood  
• Thyroid tumours (observed in animal studies) 

Patients should discuss potential side effects with their healthcare provider to understand the risks and benefits of using these medications.

What’s the difference between Ozempic and Saxenda? 

While both Saxenda and Ozempic belong to the GLP-1 receptor agonist class, they have different primary indications and usage: 

• Primary Indication: Ozempic is approved in Australia for the treatment of type 2 diabetes. It is also prescribed off-label for weight management, though this use is not officially sanctioned by the Therapeutic Goods Administration. Saxenda is being phased out but has been previously approved in Australia for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity. 
• Dosage and Administration: Ozempic is usually administered once a week, while Saxenda is taken daily. The alternative to Saxenda, Wegovy, is administered once a week. 
• Efficacy: Clinical trials have shown that Ozempic can lead to significant weight loss when used in higher doses, in combination with diet and exercise. Saxenda can lead to moderate weight loss when used at the approved dose, but the higher efficacy rate of Wegovy is one of the main reasons that this medication is being discontinued. 
• Approval Status in Australia : Ozempic is approved for type 2 diabetes treatment—this medication’s use for weight management is off-label and not officially approved by the TGA. Saxenda is approved for weight management, but will not be available from the end of this year. Novo Nordisk recommends Wegovy for weight management, but its availability may be limited due to supply constraints. 

Alternative Weight Loss Solutions 

Apart from medications like Saxenda and Ozempic, there are other weight loss solutions available in Australia, including non-surgical and surgical options.

Gastric Balloons 

Gastric balloons are non-surgical, temporary weight loss solutions designed to help individuals lose weight by occupying space in the stomach, leading to reduced hunger and increased feelings of fullness.

There are different types of gastric balloons available, including the Allurion Balloon and the Orbera Balloon. 

• Allurion Balloon: The Allurion Balloon is placed in the stomach via a swallowable capsule that is then filled with water. It remains in the stomach for approximately 16 weeks before being naturally excreted. 
• Orbera Balloon: The Orbera Balloon is inserted endoscopically and remains in the stomach for six months. It is then removed endoscopically. 

Both types of gastric balloons aim to promote significant weight loss by limiting the amount of food the stomach can hold, leading to earlier satiety and decreased overall food intake.

Bariatric surgery  – Gastric sleeve or gastric bypass surgery

Gastric sleeve surgery, also known as sleeve gastrectomy, or gastric bypass are surgical weight loss procedure.

This involves removing a large portion of the stomach and in the case of a sleeve gastrectomy this leaves a sleeve-shaped stomach about the size of a banana.

This significantly reduces the stomach’s capacity, leading to reduced food intake and changes in gut hormones that help with weight loss and improve diabetes control. 

Why Should You Pick A Balloon Or Bariatric surgery Over Weight Loss Medications? 

Choosing between weight loss medications and procedures like gastric balloons or bariatric surgery depends on individual circumstances and health goals: 

• Effectiveness: Surgical options often result in more significant and sustained weight loss compared to medications. Gastric balloons also provide effective, though temporary, weight loss solutions. 
• Permanence: Gastric balloons are temporary, making them a good option for those seeking a short-term solution, whereas bariatric surgery offers a more permanent solution. 
• Invasiveness: Gastric balloons are non-surgical and less invasive compared to bariatric surgery. 
• Side Effects and Risks: Surgical procedures carry risks of complications and longer recovery times compared to medications. Gastric balloons, while non-surgical, can also have side effects such as nausea and vomiting. 

Cost and Availability in Australia 

Ozempic Cost Australia 

As of August 2025, under the PBS, eligible patients with type-2 diabetes can purchase Ozempic for around $31.60 per pen, while concession card holders pay $7.70 per pen.

Without this subsidy, and for those using Ozempic for weight loss only, you may pay $140-$200 per pen, depending on the pharmacy and the exact dosage.

Ozempic Shortage Australia 

In the last year, the Ozempic supply situation has significantly improved, although some local pharmacies may still experience delays in restocking.

Ozempic Injection vs. Ozempic Pill

Currently, Ozempic is only available as an injectable therapy in Australia. An oral form of semaglutide, the active ingredient in Ozempic, is available overseas under the brand name Rybelsus. However, this oral form is not approved for use in Australia.

Why Pick Healthy Weight Australia? 

Healthy Weight Australia offers comprehensive and personalized weight management solutions, including both non-surgical and surgical options.

Here’s why you might choose Healthy Weight Australia: 

• Expertise: The team consists of experienced healthcare professionals specialised in weight management and metabolic health. 
• Personalised Care: Each patient receives a tailored treatment plan based on their unique health needs and goals. 
• Comprehensive Support: Patients have access to a range of services, including dietary advice, psychological support, and follow-up care. 
• Cutting-Edge Technology: Healthy Weight Australia uses the latest technology and techniques to ensure the best outcomes for patients. 
• Holistic Approach: The focus is not just on weight loss but on overall health improvement, addressing underlying issues like diabetes, hypertension, and more. 

When it comes to managing obesity and type 2 diabetes in Australia, Saxenda and Ozempic offer promising solutions with their respective benefits and side effects.

Understanding the differences between these medications, along with exploring alternative options like other medications gastric balloons and gastric sleeve surgery, can help individuals make informed decisions about their health.

Healthy Weight Australia stands out as a provider that offers a comprehensive and patient-centered approach to weight management, making it a strong choice for those seeking effective and sustainable solutions.